SML1420

FSL-1

≥80% (HPLC)

• Synonym(s): (R,S)-Pam2Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe-OH, Fibroblast-stimulating Lipopeptide, Pam2CGDPKHPKSF, S-[2,3-Bis[(1-Oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-a-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanine
• Empirical Formula (Hill Notation): C₈₄H₁₄₀N₁₄O₁₈S
• CAS Number: 322455-70-9
• Molecular Weight: 1666.16
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥80% (HPLC)
• form: powder
• color: white to off-white
• solubility: H₂O: soluble
• storage temp.: −20°C

Description

Biochem/physiol Actions

FSL-1 (Pam2CGDPKHPKSF) is a synthetic lipoprotein that acts as a Toll-like Receptor 2/6 (TLR2/6) agonist and activator of nuclear transcription factor NF-KB. FSL-1 is based on the N-terminal part of the 44-kDa lipoprotein LP44 of Mycoplasma salivarium. FSL-1 showed higher stimulatory activity than MALP-2 in its ability to induce TNF-α production in macrophages and NF-κB in TLR2/TLR6 transfected HEK293 cells.

FSL-1 is a bacterial-derived toll-like receptor 2/6 agonist. It is capable of increasing resistance to herpes simplex virus type 2 (HSV-2) infection.

Reconstitution

Reconstitute in endotoxin-free water.

Other Notes

Air sensitive

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable