SML1147

IQ-1

≥95% (HPLC)

• Synonym(s): 2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)-acetamide
• Empirical Formula (Hill Notation): C₂₁H₂₂N₄O₂
• CAS Number: 331001-62-8
• Molecular Weight: 362.42
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825681
• NACRES: NA.77

Properties

• assay: ≥95% (HPLC)
• form: powder
• color: yellow to orange
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: −20°C
• SMILES string: CC(C1=CC=C(N=N/C(C(N)=O)=C2NC(C)(C)CC3=C/2C=CC=C3)C=C1)=O
• InChI: 1S/C21H22N4O2/c1-13(26)14-8-10-16(11-9-14)24-25-19(20(22)27)18-17-7-5-4-6-15(17)12-21(2,3)23-18/h4-11,23H,12H2,1-3H3,(H2,22,27)/b19-18+,25-24?
• InChI key: ZXSRRUROLCGTBS-ASEVQSCHSA-N

Description

Biochem/physiol Actions

IQ-1 enhances β-catenin/CBP interactions and blocks β-catenin/p300 driven transcription, which enables mouse embryonic stem cells (ESCs) to be maintained in an undifferentiated pluripotent state, allowing expansion and self-renewal of mouse ESC populations.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable