SML0286

BMS 753

≥98% (HPLC)

• Synonym(s): 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid
• Empirical Formula (Hill Notation): C₂₁H₂₁NO₄
• CAS Number: 215307-86-1
• Molecular Weight: 351.40
• MDL number: MFCD18384955
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825294
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: ≥5 mg/mL
• storage temp.: 2-8°C
• SMILES string: CC1(C)C(=O)C(C)(C)c2cc(ccc12)C(=O)Nc3ccc(cc3)C(O)=O
• InChI: 1S/C21H21NO4/c1-20(2)15-10-7-13(11-16(15)21(3,4)19(20)26)17(23)22-14-8-5-12(6-9-14)18(24)25/h5-11H,1-4H3,(H,22,23)(H,24,25)
• InChI key: KFBPBWUZXBYJDG-UHFFFAOYSA-N

Description

Biochem/physiol Actions

BMS 753 is a very potent, specific agonist for RARa (Ki = 2 nM). BMS 753 does not display significant effects on RARg in reporter based assays, or in binding assays measuring displacement of labeled retinoic acid.

Features and Benefits

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable