SML0069

NSC 33994

≥98% (HPLC)

• Synonym(s): (E)-4,4′-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]-phenol (9CI), 4,4′-(3E)-Hex-3-ene-3,4-diylbis{2-[(diethylamino)methyl]phenol}, G6
• Empirical Formula (Hill Notation): C₂₈H₄₂N₂O₂
• CAS Number: 82058-16-0
• Molecular Weight: 438.65
• MDL number: MFCD20488055
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825133
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥25 mg/mL
• storage temp.: 2-8°C
• SMILES string: CCN(CC)Cc1cc(ccc1O)C(\CC)=C(/CC)c2ccc(O)c(CN(CC)CC)c2
• InChI: 1S/C28H42N2O2/c1-7-25(21-13-15-27(31)23(17-21)19-29(9-3)10-4)26(8-2)22-14-16-28(32)24(18-22)20-30(11-5)12-6/h13-18,31-32H,7-12,19-20H2,1-6H3/b26-25+
• InChI key: QFNJFVBKASKGEU-OCEACIFDSA-N

Description

Application

NSC 33994 may be used in Jak2-mediated cell signaling studies.

Biochem/physiol Actions

NSC 33994 is a potent and specific Jak2 inhibitor that inhibits a notorious mutation, Jak2-V617F, found in large number of myeloproliferative neoplasms.

Potent and specific Jak2 inhibitor effective against Jak2-V617F mutation

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable