SMB01055

Colladin

≥90% (LC/MS-ELSD)

• Synonym(s): Coladin
• Empirical Formula (Hill Notation): C₂₆H₃₂O₅
• CAS Number: 28691-96-5
• Molecular Weight: 424.53
• UNSPSC Code: 12352205
• NACRES: NA.25

Properties

• biological source: plant
• assay: ≥90% (LC/MS-ELSD)
• form: solid
• mol wt: 424.53
• solubility: water: slightly soluble
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: −20°C

Description

General description

Colladin, a sesquiterpenoid coumarin, is a natural product commonly available from Ferula Sp. (F. arrigonii, F. vesceritensis, F. campestris and F. sinaica) plants. Existing research suggests that this plant-derived metabolite exerts various biological activities, including anticancer, neuroprotective, and antiglaucoma properties.

Application

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Biochem/physiol Actions

According to the existing research, Coladin exhibited notable anti-cancer properties by substantially reducing cell proliferation and mitochondrial dehydrogenase activity in mouse B16F1 melanoma cells. These effects induced apoptosis through mechanisms involving decreased mitochondrial membrane potential and mitochondrial respiratory rate, underscoring its potential as a natural anti-cancer agent. Isolated from the roots of Ferulago campestris, coladin, along with other compounds such as umbelliprenin and epielmanticine, displayed inhibitory activity against Acetylcholinesterase (AChE) with an IC50 of 0.1 mM, suggesting its potential application in the treatment of neurological disorders like Alzheimer′s disease. Coladin, identified as one of the constituents in Heptaptera triquetra fruit, exhibited remarkable inhibitory activity against acetylcholinesterase (AChE), human carbonic anhydrase isoenzyme (hCA) I, and hCA II, with IC50 values of 8.25 nM, 28.90 nM, and 43.31 nM, respectively. This highlights its potential in the development of phytotherapeutics for conditions like Alzheimer′s disease (AD) and glaucoma.

Features and Benefits

• High quality compound suitable for multiple research applications
• Compatible with HPLC and mass spectrometry techniques

Other Notes

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Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable