SAB5702066

Anti-Acetyl-p53-K382 Antibody, clone 0, Rabbit Monoclonal

• Synonym(s): BCC7,LFS1,P53,TRP53,p53,TP53,BMFS5
• UNSPSC Code: 12352203
• NACRES: NA.46

Properties

• biological source: rabbit
• Quality Level: 100
• material: colorless
• clone: 7Z8X9, monoclonal
• form: liquid
• mol wt: 53 kDa
• species reactivity: mouse, mouse
• concentration: 0.90 mg/mL
• color: colorless
• isotype: IgG
• immunogen sequence: HKKLM
• UniProt accession no.: P04637
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... TP53(7157)

Description

General description

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).

Immunogen

A synthetic acetylated peptide around K382 of human p53 (NP_000537.3).

PBS with 0.05% proclin300,50% glycerol,pH7.3.

Application

DB, WB

Safety Information

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H317,H411
• pcodes: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• Hazard Classifications: Aquatic Chronic 2 - Skin Sens. 1
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3