SAB5700279

Anti-Phospho-ATM-S1981 antibody produced in rabbit

• Synonym(s): AT1, ATA, ATC, ATD, ATDC, ATE, ATM, TEL1, TELO1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 350
• species reactivity: human
• concentration: 1.02 mg/ml
• technique(s): immunofluorescence: 1:50-1:200; western blot: 1:500-1:2000
• UniProt accession no.: Q13315
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer1981)
• Gene Information: human ... ATM(472)

Description

General description

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Immunogen

A synthetic phosphorylated peptide around S1981 of human ATM (NP_000042.3).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable