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SAB5600095

Sigma-Aldrich

Anti-Histone H3 K27M antibody, Rabbit Monoclonal

recombinant, expressed in HEK 293 cells, clone RM192, purified immunoglobulin

Synonym(s):

Anti-Histone H3 K27M, Histone H3 K27M Detection, Rabbit Anti-Histone H3 K27M

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

recombinant

expressed in HEK 293 cells

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

RM192, monoclonal
recombinant monoclonal

form

buffered aqueous glycerol solution

species reactivity

human

technique(s)

ELISA: 0.5-2 μg/mL
immunocytochemistry: 0.005-0.1 μg/mL
immunohistochemistry: 0.005-0.1 μg/mL
western blot: 0.01-1 μg/mL

isotype

IgG

NCBI accession no.

8350

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

mutation (Lys27Met)

Gene Information

human ... H3C1(8350)

Specificity

This antibody reacts to the Histone H3 K27M mutant. No cross reactivity with wild type Histone H3.

Immunogen

A peptide corresponding to Histone H3 K27M mutant.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Angela N Viaene et al.
Brain pathology (Zurich, Switzerland), 31(1), 45-60 (2020-07-19)
Congenital brain tumors are rare accounting for 0.5%-1.9% of all pediatric brain tumors. While different criteria have been used to classify a tumor as congenital, those diagnosed prior to 6 months of age are considered to be "probably" congenital in origin.
N Kfoury-Beaumont et al.
BMC biology, 20(1), 124-124 (2022-06-01)
Neurodevelopmental disorders increase brain tumor risk, suggesting that normal brain development may have protective properties. Mutations in epigenetic regulators are common in pediatric brain tumors, highlighting a potentially central role for disrupted epigenetic regulation of normal brain development in tumorigenesis.

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