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Key Documents

SAB4300130

Sigma-Aldrich

Anti-phospho-ZAP70 (pTyr319) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-FLJ17670 antibody produced in rabbit, Anti-FLJ17679 antibody produced in rabbit, Anti-SRK antibody produced in rabbit, Anti-STD antibody produced in rabbit, Anti-zeta-chain (TCR) associated protein kinase 70kDa antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~70 kDa

species reactivity

human, mouse, rat

concentration

1 mg/mL

technique(s)

indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(S-P-YP-S-D)

NCBI accession no.

NP_001070.2

UniProt accession no.

P43403

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr319)

Gene Information

human ... ZAP70(7535)

Immunogen

Peptide sequence around phosphorylation site of tyrosine 319 (S-P-Y(p)-S-D), according to the protein ZAP70.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Plays a role in T-cell development and lymphocyte activation. Essential for TCR-mediated IL-2 production. Isoform 1 induces TCR-mediated signal transduction, isoform 2 does not.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lasse Boding et al.
European journal of immunology, 44(10), 3109-3118 (2014-07-22)
Midline 1 (MID1) is a microtubule-associated ubiquitin ligase that regulates protein phosphatase 2A activity. Loss-of-function mutations in MID1 lead to the X-linked Opitz G/BBB syndrome characterized by defective midline development during embryogenesis. Here, we show that MID1 is strongly upregulated

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