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Key Documents

SAB2500127

Sigma-Aldrich

Anti-ASPORIN/ASPN antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Asporin (LRR class 1), Anti-FLJ20129, Anti-PLAP1, Anti-SLRR1C

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: suitable

UniProt accession no.

Q9BXN1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ASPN(54829)

General description

Asporin (ASPN) is an extracellular matrix (ECM) macromolecule. It is encoded by the gene mapped to human chromosome 9q22.31. ASPN is a member of small leucine-rich proteoglycan (SLRP) family.

Immunogen

Peptide with sequence C-IHENKVKKIQKDT from the internal region of the protein sequence according to NP_060150.3.

Biochem/physiol Actions

Asporin (ASPN) plays a vital role in regulation of chondrogenesis and helps to maintain the cartilage matrix. ASPN also facilitates transforming growth factor (TGF)-f-mediated signaling. It stimulates osteoblast collagen mineralization by interacting with collagen and calcium. Mutation in the gene is associated with the development of acetabular dysplasia (AD) and hip osteoarthritis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Copy number loss in the region of the ASPN gene in patients with acetabular dysplasia: ASPN CNV in acetabular dysplasia.
Sekimoto T, et al.
Bone & joint research, 6(7), 439-445 (2017)
Workshop Abstracts, 2(2), 163-163 (2005)
Asporin competes with decorin for collagen binding, binds calcium and promotes osteoblast collagen mineralization.
Kalamajski S, et al.
The Biochemical Journal, 423(1), 53-59 (2009)
The CALM1 core promoter polymorphism is not associated with hip osteoarthritis in a United Kingdom Caucasian population.
Loughlin J, et al.
Osteoarthritis and Cartilage, 14(3), 295-298 (2006)

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