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Key Documents

SAB2106808

Sigma-Aldrich

Anti-NUDT16L1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

TIRR, Tudor Interacting Repair Regulator

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

23 kDa

species reactivity

mouse, dog, rat, human, bovine, guinea pig, rabbit

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NM_032349

UniProt accession no.

Q9BRJ7

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NUDT16L1(84309)

General description

Nudix hydrolase 16 like 1 (NUDT16L1) protein belongs to a nucleoside diphosphate-linked moiety X (Nudix) hydrolases family. It is also known as TIRR (tudor interacting repair regulator), which specifically interacts with the ionizing radiation induced foci formation (IRIF) region of P53 binding protein 1 (53BP1). NUDT16L1 gene is located on human chromosome 16p13.3.

Immunogen

Synthetic peptide directed towards the middle region of human NUDT16L1

Biochem/physiol Actions

Nudix hydrolase 16 like 1 (NUDT16L1) repairs double strand breaks by masking the histone methyl-lysine binding function of P53 binding protein 1 (53BP1). NUDT16L1 acts as an inhibitor of 53BP1.

Sequence

Synthetic peptide located within the following region: LNRVLGLGLGCLRLTEADYLSSHLTEGPHRVVAHLYARQLTLEQLHAVEI

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The Nudix hydrolase superfamily
McLennan AG, et al.
Cellular and Molecular Life Sciences, 63(2), lp9l9l-lp9l9l (2006)
The p53-binding protein 1-Tudor interacting repair regulator complex participates in the DNA damage response
Zhang A, et al.
Test, jbc-M117 (2017)
The p53-binding protein 1-Tudor interacting repair regulator complex participates in the DNA damage response
Zhang A, et al.
The Journal of Biological Chemistry, jbc-M117 (2017)
The p53-binding protein 1-Tudor interacting repair regulator complex participates in the DNA damage response
Zhang A, et al.
The Journal of biological chemistry, jbc-M117 (2017)
TIRR regulates 53BP1 by masking its histone methyl-lysine binding function
Drane P et al.
Nature, 543(7644), 211-211 (2017)

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