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Key Documents

SAB1404449

Sigma-Aldrich

Monoclonal Anti-TCF4 antibody produced in mouse

clone 1G4, purified immunoglobulin, buffered aqueous solution

Synonym(s):

E2-2, ITF2, MGC149723, MGC149724, PTHS, SEF2, SEF2-1, SEF2-1A, SEF2-1B

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1G4, monoclonal

form

buffered aqueous solution

mol wt

antigen ~66.26 kDa

species reactivity

human

technique(s)

capture ELISA: suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL

isotype

IgG1κ

NCBI accession no.

BC031056

UniProt accession no.

P15884

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TCF4(6925)

General description

Transcription factor 4 (TCF4) belongs to the class A subfamily of basic helix loop helix (bHLH) transcriptional regulators, which is also called E proteins. TCF4 gene is located on human chromosome 18q21.2. TCF4 is expressed in early human embryo.

Immunogen

TCF4 (AAH31056.1, 1 a.a. ~ 365 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHTTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRN

Biochem/physiol Actions

Transcription factor 4 (TCF4) is essential for regulating Wnt-signaling pathway. It is linked to schizophrenia.

Physical form

Solution in phosphate buffered saline, pH 7.4

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Expression and splice variant analysis of human TCF4 transcription factor in esophageal cancer
He, Gang, et al.
Journal of Cancer, 6(4), 333-333 (2015)
Tcf4 can specifically recognize beta-catenin using alternative conformations
Graham, T, et al.
Nature Structural and Molecular Biology, 8(12), 1048-1048 (2001)
The importance of TCF4 gene in the etiology of recurrent depressive disorders
Mossakows, et al.
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 80 (2018)
TCF4 (e2-2; ITF2): A schizophrenia-associated gene with pleiotropic effects on human disease
Navarrete, et al.
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 162(1) (2013)
Association of polymorphisms in the intron of TCF4 gene to late-onset Fuchs endothelial corneal dystrophy: An Indian cohort study
Rao, Bhav, et al.
Indian Journal of Ophthalmology, 65(10), 931-931 (2017)
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