S9564
Amyloid Precursor Protein α, Secreted human
>90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution
Synonym(s):
sAPPα
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General description
The APP (amyloid precursor protein) gene is mapped to human chromosome 21q21.3. It encodes a integral membrane protein. APPα is a soluble protein generated by sequential cleavage with α and γ secretase.
Application
Human amyloid precursor protein α secreted, has been used in enzyme linked immunosorbent assay (ELISA).
Biochem/physiol Actions
Amyloid precursor protein α is an α-secretase-cleaved soluble protein that has been shown to have neuroprotective properties. It is derived from amyloid precursor protein. The protein consists of 612 amino acids. Several G protein-coupled receptors are known to activate α-secretase-dependent processing of APP. It has neuroprotective, neurogenic and neurotrophic functions. Amyloid precursor protein a also stimulates gene expression and protein expression.
Physical form
Solution 0.2 μm filtered, in phosphate buffered saline, pH 7.4.
Preparation Note
Expressed as a soluble protein and purified under non-denaturing conditions.
Storage Class
10 - Combustible liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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C U Pietrzik et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(4), 1770-1775 (1998-03-21)
In various species, thyrotropin (TSH) is known to stimulate both differentiation and proliferation of thyroid follicle cells. This cell type has also been shown to express members of the Alzheimer amyloid precursor (APP) protein family and to release the secretory
Soluble b-amyloid Precursor Protein Alpha Binds to p75 Neurotrophin Receptor to
Hasebe N
PLoS ONE (2013)
SnapShot: genetics of Alzheimer?s disease
Guerreiro R, et al.
Cell, 155(4), 968-968 (2013)
Therapeutic Potential of Secreted Amyloid Precursor Protein APPsa
Frontiers in Molecular Neuroscience (2017)
S W Barger et al.
Brain research. Molecular brain research, 40(1), 116-126 (1996-08-01)
A significant fraction of the beta-amyloid precursor protein is proteolytically processed to yield large secreted forms (sAPP). These proteins have pleiotropic effects which potentially involve control of gene expression. We have investigated the influence of sAPP on the class of
Articles
Alzheimer's disease (AD) is the most common cause of dementia in the elderly and is characterized by gradual loss of cognitive functions.
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