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S7826

Sigma-Aldrich

SMER3

≥98% (HPLC)

Synonym(s):

9H-Indeno-[1,2-e]-[1,2,5]-oxadiazolo-[3,4-b]-pyrazin-9-one

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About This Item

Empirical Formula (Hill Notation):
C11H4N4O2
CAS Number:
67200-34-4
Molecular Weight:
224.18
MDL number:
MFCD00451458
UNSPSC Code:
12352200
PubChem Substance ID:
329824591
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: ≥30 mg/mL

storage temp.

2-8°C

SMILES string

O=C1c2ccccc2-c3nc4nonc4nc13

InChI

1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H

InChI key

SFSSAKVWCKFRHE-UHFFFAOYSA-N

Application

SMER3 may be used in cell signaling studies.

Biochem/physiol Actions

Inhibition of SCFMet30 by SMER3 blocks the ubiquitination of Met4 and activates the Met4-containing transcription complex. The induction of MET-genes results in cell cycle arrest and reduced cell proliferation.1
Small molecule enhancer of rapamycin (SMER); specific inhibitor of Ubiquitin E3 ligase.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Mariam Aghajan et al.
Nature biotechnology, 28(7), 738-742 (2010-06-29)
The target of rapamycin (TOR) plays a central role in eukaryotic cell growth control. With prevalent hyperactivation of the mammalian TOR (mTOR) pathway in human cancers, strategies to enhance TOR pathway inhibition are needed. We used a yeast-based screen to

Articles

Oncogenes and Tumor Suppressors Reprogram Metabolism

We present an article about how proliferating cells require the biosynthesis of structural components for biomass production and for genomic replication.

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