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S0520

Sigma-Aldrich

Selenocystamine dihydrochloride

>98% (TLC), suitable for ligand binding assays

Synonym(s):

2,2′-diselenobis-Ethanamine hydrochloride (1:2)

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About This Item

Empirical Formula (Hill Notation):
C4H12N2Se2 · 2HCl
CAS Number:
3542-13-0
Molecular Weight:
318.99
MDL number:
MFCD00035445
UNSPSC Code:
12352116
PubChem Substance ID:
24899440
NACRES:
NA.26

product name

Selenocystamine dihydrochloride, powder

assay

>98% (TLC)

Quality Level

200

form

powder

technique(s)

ligand binding assay: suitable

color

yellow to orange

solubility

H2O: soluble, clear to slightly hazy

SMILES string

NCC[Se][Se]CCN.[H]Cl.[H]Cl

InChI

1S/C4H12N2Se2.ClH/c5-1-3-7-8-4-2-6;/h1-6H2;1H

InChI key

PKRYDZYGNSZBHO-UHFFFAOYSA-N

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General description

Selenocystamine dihydrochloride has a potential to block the activity of influenza A and B virus associated RNA-dependent RNA polymerase enzyme.

Application

Selenocystamine dihydrochloride has been used to determine its effect on PP2A phosphatase activity in vitro. It has also been used as a catalyst for a disulfide-cleaving reagent, dithiothreitol (DTT).

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Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificates of Analysis (COA)

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Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer?s disease model
Corcoran NM, et al.
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 17(8), 1025-1033 (2010)
Conquest of viral diseases: a topical review of drugs and vaccines, 1 (1985)
Di Ding et al.
Biochemical and biophysical research communications, 361(3), 629-633 (2007-08-04)
Two distinct stereospecific methionine sulfoxide reductases (Msr), MsrA and MsrB reduce the oxidized methionine (Met), methionine sulfoxide [Met(O)], back to Met. In this report, we examined the reducing systems required for the activities of two chloroplastic MsrB enzymes (NtMsrB1 and
Y Hou et al.
Biochemical and biophysical research communications, 228(1), 88-93 (1996-11-01)
Seleno compounds such as selenocystamine and seleno-D, L-cystine were found to catalyze the decomposition of S-nitrosothiols (e.g. S-nitroso-glutathione and S-nitroso-N-acetyl-D, L-penicillamine) in the presence of different thiols (e.g. glutathione, N-acetyl-D-penicillamine and 2-mercaptoethanol), and liberate nitric oxide. It was also found
Transferrin serves as a mediator to deliver organometallic ruthenium (II) anticancer complexes into cells
Guo W, et al.
Inorganic Chemistry, 52(9), 5328-5338 (2013)
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