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PZ0123

Sigma-Aldrich

Avridine

≥97% (HPLC)

Synonym(s):

CP 20961, N,N-Dioctadecyl-N′,N′-bis(2-hydroxyethyl)-1,3-diaminopropane, N,N-Dioctadecyl-N′,N′-bis(2-hydroxyethyl)propanediamine

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About This Item

Empirical Formula (Hill Notation):
C43H90N2O2
CAS Number:
35607-20-6
Molecular Weight:
667.19
MDL number:
MFCD00673242
UNSPSC Code:
51111800
PubChem Substance ID:
329823713
NACRES:
NA.77

assay

≥97% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: ≥5 mg/mL (with warming to 60 °C for 5 minutes)

storage temp.

room temp

SMILES string

CCCCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCCCC)CCCN(CCO)CCO

InChI

1S/C43H90N2O2/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-36-44(38-35-39-45(40-42-46)41-43-47)37-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h46-47H,3-43H2,1-2H3

InChI key

WXNRAKRZUCLRBP-UHFFFAOYSA-N

Biochem/physiol Actions

Avridine is a potent synthetic adjuvant that can induce arthritis in most rat strains; immunomodulator and interferon-inducing.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
040M4708

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S Tanaka et al.
Immunopharmacology, 40(1), 21-26 (1998-10-17)
We evaluated the immunopharmacological effects of two novel dipeptidyl peptidase IV (DP IV) inhibitors, TMC-2A [(2S,2S',2S'')-2-[2'-[2''-amino-3''-(-indol-3'''-yl)-1''-oxopropyl]-1',2 ',3',4'-tetrahydro-6',8'-dihydroxy-7'-methoxyisoquinol-3-yl-car bonylamino]-4-hydroxymethyl-5-hydroxypentanoic acid] and TSL-225 (tryptophyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid). TMC-2A, produced by Aspergillus sp. A374, inhibited rat kidney DP IV uncompetitively, with a Ki value of
S Tanaka et al.
International journal of immunopharmacology, 19(1), 15-24 (1997-01-01)
Dipeptidyl peptidase IV (DP IV, CD26) is a serine exoprotease which selectively cleaves the penultimate proline residue of polypeptides. This enzyme is also expressed as a surface marker on activated T cells. In order to assess the relevance of DP
J G Brun et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 103(3), 233-240 (1995-03-01)
Plasma levels of calprotectin correlate with disease activity and clinical assessments of arthritis in various rheumatic diseases, and high levels have been demonstrated in the synovial fluid of patients with rheumatoid arthritis. However, the role of calprotectin in rheumatic inflammation
A Berinstein et al.
Vaccine, 11(13), 1295-1301 (1993-10-01)
Foot-and-mouth disease is one of the more economically important diseases among meat-producing biungulate species. In contrast to natural infection, current foot-and-mouth disease virus (FMDV) vaccines, prepared with inactivated virus and adjuvants, elicit short-lived protection. The immunomodulating effect on FMDV vaccines
Comparative susceptibility of DA, LEW, and LEW.1AV1 rats to arthritis induced with different arthritogens: mineral oil, mycobacteria, muramyl dipeptide, avridine and rat collagen type II.
J C Lorentzen et al.
Transplantation proceedings, 29(3), 1692-1693 (1997-05-01)
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