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P7780

Sigma-Aldrich

Propionylpromazine hydrochloride

Synonym(s):

Propiopromazine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C20H24N2OS · HCl
CAS Number:
7681-67-6
Molecular Weight:
376.94
Beilstein/REAXYS Number:
38502
MDL number:
MFCD01941563
UNSPSC Code:
12352200
PubChem Substance ID:
24278651
NACRES:
NA.77

form

powder

storage temp.

2-8°C

SMILES string

Cl.CCC(=O)c1ccc2Sc3ccccc3N(CCCN(C)C)c2c1

InChI

1S/C20H24N2OS.ClH/c1-4-18(23)15-10-11-20-17(14-15)22(13-7-12-21(2)3)16-8-5-6-9-19(16)24-20;/h5-6,8-11,14H,4,7,12-13H2,1-3H3;1H

InChI key

ZFWVWZODBGTOIL-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813)

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Biochem/physiol Actions

Phenothiazine antipsychotic; D2 dopamine receptor antagonist.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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Y Govaert et al.
The Analyst, 123(12), 2507-2512 (1999-08-06)
A rapid and sensitive multi-residue method was developed to attempt to confirm the presence of the beta-blocker carazolol and the tranquillizers acepromazine, azaperone, chlorpromazine, propionylpromazine and xylazine in pig muscle tissues. The procedure involves determination by liquid chromatography coupled with
Residues of some veterinary drugs in animals and foods. Monographs prepared by the thirty-eighth meeting of the Joint FAO/WHO Expert Committee on Food Additives.
FAO food and nutrition paper, 41(4), 1-136 (1991-01-01)
M Olling et al.
Journal of veterinary pharmacology and therapeutics, 4(4), 291-294 (1981-12-01)
A thin-layer chromatographic method for the determination of the veterinary tranquillizer propiopromazine (Combelen) in slaughter pigs is described. Propiopromazine residue depletion from the kidney occurs with different rates in sows and in castrated boars. In the liver residues increase over
J Park et al.
Journal of chromatography, 489(2), 313-321 (1989-04-14)
The propionylpromazine concentrations in plasma after intramuscular administration to horses were determined using gas chromatography with nitrogen-phosphorus detection. After hydrolysis by beta-glucuronidase/arylsulphatase, the parent drug and three metabolites were detected in urine. The metabolites were identified as 2-(1-hydroxypropyl)promazine, 2-(1-propenyl)promazine and
D B Hurlbut et al.
Journal of AOAC International, 82(6), 1321-1328 (1999-12-10)
Propionylpromazine hydrochloride (PPZHCl) has been investigated for use with leghold traps to reduce the amount of self-inflicted trauma experienced by animals restrained by these traps. Three types of PPZHCl formulations made with Karo dark syrup, K-Y Jelly, and Vaseline were
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