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P5556

Sigma-Aldrich

Poloxamer 188 solution

10%, sterile-filtered, BioReagent, suitable for insect cell culture

Synonym(s):

Nonionic copolymer surfactant

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About This Item

CAS Number:
9003-11-6
MDL number:
MFCD00082049
UNSPSC Code:
12161902
PubChem Substance ID:
24898666
NACRES:
NA.75

description

non-ionic

Quality Level

400

sterility

sterile-filtered

product line

BioReagent

mol wt

average mol wt 8350

concentration

10%

technique(s)

cell culture | insect: suitable

impurities

endotoxin, tested

CMC

0.04 mM

transition temp

cloud point ≥100

HLB

29

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

General description

Poloxamer 188 (P188) is a non-ionic amphiphilic copolymer. It comprises a central chain of hydrophobic polyoxypropylene flanked at ends by hydrophilic polyoxyethylene.

Application

A nonionic copolymer surfactant

Biochem/physiol Actions

Poloxamer 188 (P188) elicits hemorheological, antithrombotic, anti-inflammatory, and cytoprotective activities. It restores and stabilizes membrane barrier function. P188 also inhibits lipid peroxidation, reduces surface tension and hydrophobic-based cellular adherence. P-188 exhibits low toxicity and may be used in oral drug delivery.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificates of Analysis (COA)

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Dina Mourad Saleh et al.
Particle and fibre toxicology, 17(1), 48-48 (2020-10-16)
Multi-walled carbon nanotubes can be divided into two general subtypes: tangled and straight. MWCNT-N (60 nm in diameter) and MWCNT-7 (80-90 nm in diameter) are straight-type MWCNTs, and similarly to asbestos, both are carcinogenic to the lung and pleura when administered to
Rahul P Bakshi et al.
Nature communications, 9(1), 315-315 (2018-01-24)
Chemoprophylaxis is currently the best available prevention from malaria, but its efficacy is compromised by non-adherence to medication. Here we develop a long-acting injectable formulation of atovaquone solid drug nanoparticles that confers long-lived prophylaxis against Plasmodium berghei ANKA malaria in
Daniel Helman et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 85(2), 162-168 (2013-06-15)
We developed a membrane bound reporter and selection molecule for sorting by fluorescence activated cell sorting (FACS) of cells producing a protein of interest. This molecule is composed of a transmembrane (TM) domain, fused on its extracellular end to a
Mimi R Borrelli et al.
Stem cells translational medicine, 9(11), 1389-1400 (2020-06-17)
Fat grafting is a surgical technique able to reconstruct and regenerate soft tissue. The adipose-derived stromal cells (ASCs) within the stromal vascular fraction are believed to drive these beneficial effects. ASCs are increasingly recognized to be a heterogeneous group, comprised
Bill T V Duong et al.
EBioMedicine, 61, 103031-103031 (2020-10-13)
Malignant pleural mesothelioma (MPM) is an aggressive cancer related to asbestos exposure. Early diagnosis is challenging due to generic symptoms and a lack of biomarkers. We previously demonstrated that mesothelial precursor cells (MPC) characterized by mesothelin (MSLN)+CD90+CD34+ could be implicated
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