P1247
Anti-Peroxiredoxin 3 antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(s):
Anti-AOP1, Anti-Antioxidant Protein 1, Anti-PRDX3
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About This Item
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biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~25 kDa
species reactivity
human
technique(s)
microarray: suitable
western blot: 1:4,000-1:8,000 using HeLa cell mitochondria extracts
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PRDX3(10935)
General description
PRDX3, also known as antioxidant protein 1 (AOP1), MER-5, or SP-22, belongs to a family of proteins termed peroxiredoxins (Prx). It is a mitochondrial protein.
The PRDX3 gene is located on the human chromosome at 10q26.11.
Specificity
Whole antiserum is purified to provide an IgG fraction of antiserum Anti-Peroxiredoxin 3 recognizes human PRDX3.
Immunogen
synthetic peptide corresponding to amino acids 241-256 of human peroxiredoxin 3, conjugated to KLH via an N-terminal lysine residue.
Application
Anti-Peroxiredoxin 3 antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
Peroxiredoxin 3 (PRDX3) catalyzes the reduction of peroxides in the presence of thioredoxin. The Prx family has been identified in association with a variety of diverse cellular functions including growth control, proliferation, differentiation, and in the response to oxidative stress. PRDX3 is required to maintain normal mitochondrial function through direct activation by c-Myc, which may explain its overexpression during neoplastic transformation.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in frost-free freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
11 - Combustible Solids
Certificates of Analysis (COA)
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Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria
Chang TM, et al.
The Journal of Biological Chemistry, 279(40), 41975-41984 (2004)
Afsane Bahrami et al.
Journal of cellular physiology, 233(3), 1929-1939 (2017-05-26)
Cervical cancer (CC) is the third most common malignancy in women globally, and persistent infection with the oncogenic human papillomaviruses (HPV) is recognized as the major risk factor. The pathogenesis of CC relies on the interplay between the tumorigenic properties
J G van Andel
Radiologia clinica, 46(1), 50-69 (1977-01-01)
80 patients with carcinoma of the nasopharynx classified according to TNM categories who have been treated in the RRTI between January 1947 and January 1966 are discussed. During 1947-1957 patients were treated by orthovoltage, and after this period by cobalt
Peroxiredoxin 3 levels regulate a mitochondrial redox setpoint in malignant mesothelioma cells
Cunniff B, et al.
Redox Biology, 3(40), 79-87 (2014)
Pauline J van der Watt et al.
Molecular cancer therapeutics, 15(4), 560-573 (2016-02-03)
Karyopherin beta 1 (Kpnβ1) is a nuclear transport receptor that imports cargoes into the nucleus. Recently, elevated Kpnβ1 expression was found in certain cancers and Kpnβ1 silencing with siRNA was shown to induce cancer cell death. This study aimed to
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