O7635

Anti-Osteopontin antibody produced in goat

affinity isolated antibody, lyophilized powder

• Synonym(s): Anti-OPN
• MDL number: MFCD02263865
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: goat
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• species reactivity: mouse
• technique(s): capture ELISA: 0.2-0.8 μg/mL; immunohistochemistry: 5-15 μg/mL using mouse thymus tissue sections; neutralization: 1-3 μg/mL; western blot: 0.1-0.2 μg/mL
• UniProt accession no.: P10923
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: mouse ... Spp1(20750)

Description

General description

The OPN (osteopontin) gene is mapped to mouse chromosome 5 E5 and codes for secreted phosphoprotein 1 and is mostly expressed in bone tissue.

Immunogen

purified recombinant mouse osteopontin expressed in NSO cells.

Biochem/physiol Actions

Osteopontin (OPN) serves as a ligand to a number of integrin receptors which are associated with cell motility, chemotaxis, invasion and cell survival. Upregulation of OPN gene is observed in tumors such as colorectal carcinomas, breast cancer and contributes to its pathogenesis. OPN is associated with obesity by mediating adipocyte inflammation and insulin resistance upon macrophage activation. OPN functions as an effector molecule in extracellular signalling and promotes fibrosis and myocyte growth.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Analysis Note

Neutralizes the biological activity of recombinant mouse osteopontin using 293 cells.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable