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O3007

Sigma-Aldrich

Ochratoxin A−BSA conjugate from Aspergillus ochraceus

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About This Item

CAS Number:
303-47-9
MDL number:
MFCD00078079
UNSPSC Code:
12352200
PubChem Substance ID:
24897972
NACRES:
NA.77

extent of labeling

3-6 mol ochratoxin A per mol BSA

Quality Level

200

storage temp.

2-8°C

SMILES string

O=C1O[C@H](C)CC2=C(Cl)C=C(C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)C(O)=C21

InChI

1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15+/m1/s1

InChI key

RWQKHEORZBHNRI-BMIGLBTASA-N

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Application

Ochratoxin A−BSA conjugate from Aspergillus ochraceus has been used in carbonate-bicarbonate buffer to coat the high-affinity 96-well polystyrene plates for indirect competitive enzyme-linked immunosorbent assay. It has also been used as a standard in the determination of ochratoxin A in serum by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF).

Biochem/physiol Actions

Ochratoxin A (OTA) is a mycotoxin that is the most toxic among the other ochratoxins. It is produced by Aspergillus carbonarius, A. ochraceus, and Penicillium verrucosum. OTA acts as a major food contaminant and is considered nephrotoxic, teratogenic, neurotoxic, hepatotoxic, and immunotoxic. OTA is known to elevate oxidative stress at a cellular level.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Carc. 1B - Repr. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Production of an ochratoxin A antigen with high hapten/carrier molar ratio.
H Worsaae
Acta pathologica et microbiologica Scandinavica. Section C, Immunology, 86C(4), 203-204 (1978-08-01)
Benedikt Cramer et al.
Bioorganic & medicinal chemistry, 18(1), 343-347 (2009-11-19)
The mycotoxin ochratoxin A is a potent inhibitor of the protein biosynthesis and known to be cytotoxic in nanomolar concentrations. In order to investigate the relationship between stereochemistry and cytotoxicity of this compound, all four ochratoxin A stereoisomers have been
Maria-Teresa Gutierrez-Lugo et al.
Bioorganic & medicinal chemistry letters, 21(8), 2480-2483 (2011-03-12)
The cysteinyl transferase mycothiol ligase, or MshC, catalyzes the fourth step in the biosynthesis of the small molecular weight thiol mycothiol. MshC is essential for growth of Mycobacterium tuberculosis. Two groups of known aminoacyl tRNA synthetase inhibitors were evaluated for
Gregory Kaler et al.
The Journal of biological chemistry, 282(33), 23841-23853 (2007-06-08)
Organic anion transporters (OATs, SLC22) interact with a remarkably diverse array of endogenous and exogenous organic anions. However, little is known about the structural features that determine their substrate selectivity. We examined the substrate binding preferences and transport function of

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