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N4413

Sigma-Aldrich

Anti-Nanog antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-FLJ12581, Anti-Nanog homeobox

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

concentration

~1 mg/mL

technique(s)

western blot: 1:1,000-1:2,000

UniProt accession no.

Q9H9S0

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NANOG(79923)
mouse ... Nanog(71950)
rat ... Nanog(414065)

General description

Nanog homeobox (NANOG) is a 305 amino acid transcription factor. It is expressed in many types of cancers.

Immunogen

synthetic peptide corresponding to an internal sequence of human Nanog.

Biochem/physiol Actions

Nanog homeobox (NANOG) works with pluripotency factors like sex determining region Y-box 2 (SOX2). It is involved in conserving the pluripotency and self-renewal properties of embryonic stem cells. NANOG also associates with the c-Jun promoter.

Physical form

solution in phosphate buffered saline, containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

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Certificates of Analysis (COA)

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NANOG upregulates c-Jun oncogene expression through binding the c-Jun promoter.
Lin Y
Molecular Carcinogenesis, 54(11), 1407-1416 (2015)
Shuai Gong et al.
Molecular carcinogenesis, 54(9), 679-687 (2015-05-28)
As one of the key pluripotency transcription factors, NANOG plays a critical role in maintaining the self-renewal and pluripotency in normal embryonic stem cells. Recent data indicate that NANOG is expressed in a variety of cancers and its expression correlates
Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.
Hayashi Y
Proceedings of the National Academy of Sciences of the USA, 112(15), 4666-4671 (2015)
Yongyu Wang et al.
Biomaterials, 35(32), 8960-8969 (2014-08-03)
Tissue-engineered blood vessels (TEBVs) are promising in the replacement of diseased vascular tissues. However, it remains a great challenge to obtain a sufficient number of functional smooth muscle cells (SMCs) in a clinical setting to construct patient-specific TEBVs. In addition
Miriama Krutá et al.
Stem cells and development, 23(20), 2443-2454 (2014-05-20)
The genomic destabilization associated with the adaptation of human embryonic stem cells (hESCs) to culture conditions or the reprogramming of induced pluripotent stem cells (iPSCs) increases the risk of tumorigenesis upon the clinical use of these cells and decreases their
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