N3040

Necrostatin-7

≥98% (HPLC), powder

• Synonym(s): 5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone, Nec-7
• Empirical Formula (Hill Notation): C₁₆H₁₀FN₅OS₂
• CAS Number: 351062-08-3
• Molecular Weight: 371.41
• MDL number: MFCD02334728
• UNSPSC Code: 12352202
• PubChem Substance ID: 329818601

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: yellow to tan
• solubility: DMSO: >10 mg/mL (with warming)
• storage temp.: 2-8°C
• SMILES string: Fc1ccc(cc1)-c2n[nH]cc2C=C3SC(=N)N(C3=O)c4nccs4
• InChI: 1S/C16H10FN5OS2/c17-11-3-1-9(2-4-11)13-10(8-20-21-13)7-12-14(23)22(15(18)25-12)16-19-5-6-24-16/h1-8,18H,(H,20,21)
• InChI key: SMJGLNVGTJLIRV-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Necrostatin-7 (Nec-7) is a potent inhibitor of necroptosis, a regulated caspase-independent necrotic cell death pathway, distinct from apoptosis. Nec-7 has a different profile from the other necrostatins as it does not inhibit RIP1 kinase, suggesting the possibility that it may target an additional as yet unknown regulatory molecule in the pathway.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable