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N2162

Sigma-Aldrich

NH125

≥98% (HPLC), solid

Synonym(s):

1-Benzyl-3-cetyl-2-methylimidazolium iodide

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About This Item

Empirical Formula (Hill Notation):
C27H45IN2
CAS Number:
278603-08-0
Molecular Weight:
524.56
MDL number:
MFCD07370143
UNSPSC Code:
12352200
PubChem Substance ID:
329818598
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white to off-white

mp

88.2-94.9 °C

solubility

DMSO: >20 mg/mL

storage temp.

−20°C

SMILES string

[I-].CCCCCCCCCCCCCCCC[n+]1ccn(Cc2ccccc2)c1C

InChI

1S/C27H45N2.HI/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-28-23-24-29(26(28)2)25-27-20-17-16-18-21-27;/h16-18,20-21,23-24H,3-15,19,22,25H2,1-2H3;1H/q+1;/p-1

InChI key

RVWOHCBHAGBLLT-UHFFFAOYSA-M

Biochem/physiol Actions

NH125 exhibits anti-proliferation activity against many cancer cells. It also exhibits antibacterial effects by inhibiting bacterial histidine protein kinase.
NH125 is a novel plant histidine kinase inhibitor and selective mammalian eurkaryotic elongation factor-2 kinase (eEF-2K).

Packaging

Packaged under nitrogen.

Analysis Note

IC50 = 60 nM for eEF-2 kinase vs protein kinase C (IC50= 7.5 μM), protein kinase A (IC50= 80 μM), and calmodulin-dependent kinase II IC50 > 100 μM).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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