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I3657

Sigma-Aldrich

Insulin-Like Growth Factor Binding Protein-2 from mouse

≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

Synonym(s):

IGFBP-2

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About This Item

MDL number:
MFCD02099094
UNSPSC Code:
51111800
NACRES:
NA.32

biological source

mouse

Quality Level

200

recombinant

expressed in NSO cells

assay

≥95% (SDS-PAGE)

form

lyophilized powder

potency

0.125-0.5 mg per mL ED50

mol wt

~35 kDa by SDS-PAGE (reducing)
calculated mol wt 29.4 kDa

packaging

pkg of 25 μg

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

D3YU40

storage temp.

−20°C

Gene Information

mouse ... Igfbp2(16008)

General description

IGFBP2 (insulin-like growth factor binding protein 2) belongs to the IGFBP family of proteins. The protein has two HBD (heparin-binding domain-1) domains. It is a secreted protein.

Biochem/physiol Actions

During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.
IGFBP2 (insulin-like growth factor binding protein 2) works along with IGF-I (insulin like growth factor I) and regulates cellular proliferation and differentiation. It mainly binds to IGFs and restricts their association to other receptors.

Physical form

Lyophilized from a 0.2 μm filtered solution of 35% acetonitrile and 0.1% TFA.

Analysis Note

The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Gang Xi et al.
Endocrinology, 154(11), 4146-4157 (2013-08-29)
IGF-binding protein (IGFBP)-2 overexpression confers resistance to high-fat feeding and inhibits the differentiation of preadipocytes in vitro. However, whether administration of IGFBP-2 can regulate adipogenesis in vivo and the domains that mediate this response have not been defined. IGFBP-2 contains
Hye Suk Kang et al.
The Biochemical journal, 467(3), 453-460 (2015-02-20)
Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorders is well known, its regulatory mechanism remains unclear. In
Gang Xi et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 29(11), 2427-2438 (2014-05-20)
Insulin-like growth factor binding protein 2 (IGFBP-2) is important for acquisition of normal bone mass in mice; however, the mechanism by which IGFBP-2 functions is not defined. These studies investigated the role of IGFBP-2 in stimulating osteoblast differentiation. MC-3T3 preosteoblasts
Xinchun Shen et al.
The Journal of biological chemistry, 290(18), 11578-11590 (2015-03-20)
Insulin-like growth factor-binding protein-2 (IGFBP-2) functions coordinately with IGF-I to stimulate cellular proliferation and differentiation. IGFBP-2 binds to receptor tyrosine phosphatase β (RPTPβ), and this binding in conjunction with IGF-I receptor stimulation induces RPTPβ polymerization leading to phosphatase and tensin

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