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I0763

Sigma-Aldrich

N9-Isopropylolomoucine

≥98% (HPLC)

Synonym(s):

2-(2′-Hydroxyethylamino)-6-benzylamino-9-isopropylpurine

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About This Item

Empirical Formula (Hill Notation):
C17H22N6O
CAS Number:
158982-15-1
Molecular Weight:
326.40
MDL number:
MFCD01310377
UNSPSC Code:
12352202
PubChem Substance ID:
329815325
NACRES:
NA.77

assay

≥98% (HPLC)

form

solid

storage temp.

−20°C

SMILES string

CC(C)n1cnc2c(NCc3ccccc3)nc(NCCO)nc12

InChI

1S/C17H22N6O/c1-12(2)23-11-20-14-15(19-10-13-6-4-3-5-7-13)21-17(18-8-9-24)22-16(14)23/h3-7,11-12,24H,8-10H2,1-2H3,(H2,18,19,21,22)

InChI key

WHDJEAZLMYPLGL-UHFFFAOYSA-N

Biochem/physiol Actions

Inhibitor of certain cyclin-dependent kinases; increased potency in some systems over olomoucine.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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J Veselý et al.
European journal of biochemistry, 224(2), 771-786 (1994-09-01)
While testing purines related to the non-specific protein kinase inhibitors N6-dimethylaminopurine and N6-(delta 2-isopentenyl)adenine as potential inhibitors of the p34cdc2/cyclin B kinase, we discovered a compound with high specificity, 2-(2-hydroxyethylamino)-6- benzylamino-9-methylpurine (olomoucine). Kinetic analysis of kinase inhibition reveals that olomoucine

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