H9772

5-Hydroxy-L-tryptophan

powder

• Synonym(s): L-2-Amino-3-(5-hydroxyindolyl)propionic acid, L-5-HTP
• Empirical Formula (Hill Notation): C₁₁H₁₂N₂O₃
• CAS Number: 4350-09-8
• Molecular Weight: 220.22
• EC Number: 224-411-1
• MDL number: MFCD00064341
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 24278131
• NACRES: NA.77

Properties

• assay: ≥98% (TLC)
• Quality Level: 200
• form: powder
• technique(s): HPLC: suitable
• color: white to faint beige
• storage temp.: 2-8°C
• SMILES string: N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(O)=O
• InChI: 1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1
• InChI key: LDCYZAJDBXYCGN-VIFPVBQESA-N
• Gene Information: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363)

Description

General description

5-Hydroxy-L-tryptophan (5-HTP) is naturally found in Griffonia simplicifolia.

Application

5-Hydroxy-L-tryptophan has been used:

• to inject experimental mice for serotonin detection
• as a precursor of 5-hydroxytryptamine and injected in pregnant mice and neonatal rats for vital neutral red staining of lung slices
• as a standard in citrate-acetate buffer for its use in high performance liquid chromatography (HPLC) analysis

Biochem/physiol Actions

Hydroxylation of L-tryptophan occurs in the brain during serotonin synthesis. This is a step that controls the production of serotonin and also yields 5-hydroxy-l-tryptophan (5-HTP) as a metabolite. Thus, consumption 5-HTP, increases the serotonin level, which might result in depression, lack of sleep and severe headache.

Immediate precursor of serotonin; L-aromatic amino acid decarboxylase substrate.

Caution

Light sensitive

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves