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G9885

Sigma-Aldrich

α1-Acid Glycoprotein from human plasma

≥99% (agarose gel electrophoresis)

Synonym(s):

AGP, Orosomucoid

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About This Item

CAS Number:
66455-27-4
MDL number:
MFCD00131224
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human plasma

Quality Level

200

assay

≥99% (agarose gel electrophoresis)

form

powder

technique(s)

ELISA: suitable

impurities

HIV-1/HIV-2, HCV and hepatitis B antigen, tested negative

UniProt accession no.

P02763

storage temp.

2-8°C

Gene Information

human ... ORM1(5004)

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General description

α-1-Acid glycoprotein (AGP)/orosomucoid (ORM), a glycoprotein has a molecular weight of 41-43kDa. It is considered as one of the important acute phase proteins in humans and rats. AGP may belong to the lipocalin family.

Application

α1-Acid glycoprotein from human plasma has been used:
  • as negatively charged protein to investigate the adsorption processes onto the surface of polyelectrolyte multilayers
  • to incubate plates coated with purified antiserum in the study to investigate its serum concentration by ELISA
  • to study the effect of its different concentrations on the antiviral activity of human immunodeficiency virus (HIV) protease inhibitors

Biochem/physiol Actions

α1-Acid glycoprotein possesses immunomodulating effects. It has the ability to bind to acidic drugs, like phenobarbital.

Preparation Note

Purified from Cohn Fraction VI

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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In Vitro Effect of alpha1-Acid Glycoprotein on the Anti?Human Immunodeficiency Virus (HIV) Activity of the Protease Inhibitor CGP 61755: A Comparative Study with Other Relevant HIV Protease Inhibitors
Lazdins J K, et al.
The Journal of Infectious Diseases, 175(5), 1063-1070 (1997)
Hendrik Grootaert et al.
Glycobiology, 30(9), 735-745 (2020-03-10)
The deoxy sugar l-fucose is frequently found as a glycan constituent on and outside living cells, and in mammals it is involved in a wide range of biological processes including leukocyte trafficking, histo-blood group antigenicity and antibody effector functions. The
Effect of once weekly administration of mifepristone on ovarian function in normal women
Chen X and Xiao B
Contraception, 56(3), 175-180 (1997)
Protein adsorption onto auto-assembled polyelectrolyte films
Ladam G, et al.
Langmuir, 17(3), 878-882 (2001)
Alpha-1-acid glycoprotein
Fournier T, et al.
Biochimica et Biophysica Acta, 1482(1-2), 157-171 (2000)
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