G6752

Guanosine

≥98%

• Synonym(s): 9-(β-D-Ribofuranosyl)guanine, Guanine-9-β-D-ribofuranoside
• Empirical Formula (Hill Notation): C₁₀H₁₃N₅O₅
• CAS Number: 118-00-3
• Molecular Weight: 283.24
• Beilstein/REAXYS Number: 625911
• EC Number: 204-227-8
• MDL number: MFCD00010182
• UNSPSC Code: 41106305
• PubChem Substance ID: 24895268
• NACRES: NA.51

Properties

• biological source: microbial
• Quality Level: 100; 200
• assay: ≥98%
• form: powder
• mp: 250 °C (dec.) (lit.)
• solubility: formic acid:water (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• SMILES string: [H]O[H].NC1=Nc2c(ncn2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1
• InChI: 1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1
• InChI key: NYHBQMYGNKIUIF-UUOKFMHZSA-N

Description

General description

Guanosine is an aromatic organic molecule and a purine nucleoside. It is present in the cerebrospinal fluid, intestinal cells, blood-brain barrier and in brain microvessels.

Application

Guanosine has been used:

• as a reference standard for the analysis of glucosinolates by high-performance liquid chromatography with diode-array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD-ESI/MS)
• as a component of Mouse Embryonic Fibroblasts (MEFs) culture
• as a standard for the detection of residual RNA contaminant in oil palm plant genome samples by HPLC

Biochem/physiol Actions

Guanosine nucleoside elicits cellular effect as the guanine-based purinergic system. It modulates glutamate uptake by glutamate transporters. It may have neuroprotective functionality in central nervous system disorders. Guanosine promotes neurite arborization, outgrowth, proliferation and differentiation. Administration of guanosine replenished GTP and elicits protective function in renal ischemic injury.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges