E9645
Estrone sulfamate
≥98%
Synonym(s):
1,3,5(10)-Estratrien-17-one 3-sulfamate
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About This Item
Empirical Formula (Hill Notation):
C18H23NO4S
CAS Number:
Molecular Weight:
349.44
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77
Recommended Products
biological source
synthetic (organic)
Quality Level
assay
≥98%
form
powder
storage temp.
−20°C
InChI
1S/C18H23NO4S/c1-18-9-8-14-13-5-3-12(23-24(19,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16H,2,4,6-9H2,1H3,(H2,19,21,22)/t14-,15-,16+,18+/m1/s1
InChI key
RVKFQAJIXCZXQY-CBZIJGRNSA-N
Application
Lead compound for design of steroid sulfatase inhibitors.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamates.
L W Woo et al.
Journal of medicinal chemistry, 39(7), 1349-1351 (1996-03-29)
A Purohit et al.
Biochemistry, 34(36), 11508-11514 (1995-09-12)
Steroid sulfatases are responsible for the hydrolysis of 3beta-hydroxy steroid sulfates, such as cholesterol and pregnenolone sulfate, and have an important role in regulating the synthesis of estrogenic steroids, from estrone sulfate and dehydroepiandrosterone sulfate, in endocrine-dependent tumors. Although little
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