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E1904

Sigma-Aldrich

Ethyl-3,4-dephostatin

>99% (HPLC), solid

Synonym(s):

3,4-Dihydroxy-N-ethyl-N-nitrosoaniline

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About This Item

Empirical Formula (Hill Notation):
C8H10N2O3
CAS Number:
237756-11-5
Molecular Weight:
182.18
MDL number:
MFCD04040000
UNSPSC Code:
12352200
PubChem Substance ID:
24894445
NACRES:
NA.77

Quality Level

100

assay

>99% (HPLC)

form

solid

color

brown

solubility

DMSO: soluble 22 mg/mL
H2O: soluble 8 mg/mL

storage temp.

2-8°C

SMILES string

CCN(N=O)c1ccc(O)c(O)c1

InChI

1S/C8H10N2O3/c1-2-10(9-13)6-3-4-7(11)8(12)5-6/h3-5,11-12H,2H2,1H3

InChI key

ZTXUSFPBLYQDDN-UHFFFAOYSA-N

Biochem/physiol Actions

Stable analog of dephostatin. Selective inhibitor of protein tyrosine phosphatase 1B and SHPTP-1. Does not inhibit CD45-associated phosphatases.

Features and Benefits

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Caution

Store under nitrogen

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hypoxia enhances the proliferation and migration of adipose-derived stem cells (ASCs) via the generation of reactive oxygen species (ROS). Therefore, this study primarily investigated whether or not ROS generation could regulate microRNA-210 (miR-210) expression, and increase proliferation/migration of ASCs. In

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