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D0633

Sigma-Aldrich

7-(2,3-Dihydroxypropyl)theophylline

Synonym(s):

7-(2,3-Dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione, Diprophylline, Dyphylline

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About This Item

Empirical Formula (Hill Notation):
C10H14N4O4
CAS Number:
479-18-5
Molecular Weight:
254.24
Beilstein/REAXYS Number:
284563
EC Number:
207-526-1
MDL number:
MFCD00005759
UNSPSC Code:
41106305
PubChem Substance ID:
24893280
NACRES:
NA.77

form

powder

mp

161-162 °C (lit.)

SMILES string

CN1C(=O)N(C)c2ncn(CC(O)CO)c2C1=O

InChI

1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3

InChI key

KSCFJBIXMNOVSH-UHFFFAOYSA-N

Gene Information

human ... PDE3A(5139) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)

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Biochem/physiol Actions

7-(2,3-Dihydroxypropyl)theophylline is also called as dyphylline. Dyphylline serves as a bronchodilator and aids in better air flow through the lungs. It reduces the symptoms of chronic lung disorder such as asthma and bronchitis.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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F Siepmann et al.
Journal of controlled release : official journal of the Controlled Release Society, 141(2), 216-222 (2009-09-10)
Kollidon SR-based matrix tablets containing various amounts of diprophylline were prepared and thoroughly characterized in vitro. This includes drug release measurements in 0.1M HCl and phosphate buffer pH 7.4, monitoring of changes in the tablet's height and diameter, morphology as
Sinan Güres et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 80(1), 122-129 (2011-10-20)
The aim of this study was to use a mechanistically realistic mathematical model based on Fick's second law to quantitatively predict the release profiles from solid lipid extrudates consisting of a ternary matrix. Diprophylline was studied as a freely water-soluble
Wei-Shan Huang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 795(2), 329-335 (2003-10-03)
A simple micellar electrokinetic chromatography is described for well resolution of theophylline, dyphylline and caffeine. The separation was performed at 25 degrees C using a background electrolyte consisting of 10mM borate buffer at pH 9 and 40 mM sodium dodecyl
Mario Grassi et al.
International journal of pharmaceutics, 276(1-2), 107-114 (2004-04-29)
A mathematical model able to describe the release kinetics of two model drugs (Diprophylline and Theophylline) from partially coated hydroxypropylmethylcellulose (HPMC, Methocel) K4M) matrices is presented. As solvent interaction with the system and drug release can only take place in
The AARP Guide to Pills: Essential Information on More Than 1,200 Prescription and Nonprescription Medicines, Including Generics, 302-302 (2006)
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Discover Bioactive Small Molecules for Cyclic Nucleotides

Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.

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