D0162
2′,3′-Dideoxyinosine
≥98% (HPLC)
Synonym(s):
ddI, ddIno
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All Photos(2)
About This Item
Empirical Formula (Hill Notation):
C10H12N4O3
CAS Number:
Molecular Weight:
236.23
Beilstein/REAXYS Number:
3619529
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.55
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Quality Level
assay
≥98% (HPLC)
form
powder
storage temp.
−20°C
SMILES string
OC[C@@H]1CC[C@@H](O1)n2cnc3C(=O)NC=Nc23
InChI
1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1
InChI key
BXZVVICBKDXVGW-NKWVEPMBSA-N
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Biochem/physiol Actions
Nucleotide antagonist
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Gilles Casano et al.
Bioorganic & medicinal chemistry, 18(16), 6012-6023 (2010-07-20)
In our search for potent anti-HIV and antiplasmodial agents, novel series of flavonoid derivatives and their chalcone intermediates were synthesized and evaluated for inhibition of HIV multiplication and antiproliferative activity on Plasmodium falciparum parasites. Chalcones exhibited a more selective antiplasmodial
Alejandro Arenas-Pinto et al.
Antiviral therapy, 17(2), 275-282 (2012-02-02)
Genetic predisposition to dideoxynucleoside-induced mitochondrial dysfunction might be related to mitochondrial DNA (mtDNA) polymorphisms. Severe hyperlactataemia is probably the best model to assess such a predisposition. For this exploratory study in White European and Black African HIV-infected adults, hypervariable region
Yue-Ping Wang et al.
European journal of medicinal chemistry, 44(3), 1016-1023 (2008-08-12)
A series of new 5-alkyl-2-benzylsulfanylpyrimidin-4(3H)-ones (5a-y) bearing different substituted arylmethyl moieties at the C-6 position of the pyrimidine core have been synthesized and evaluated for their in vitro activities against HIV-1 and HIV-2 in MT-4 cell cultures. The majority of
J N L Schouten et al.
Alimentary pharmacology & therapeutics, 36(9), 875-885 (2012-09-14)
Idiopathic noncirrhotic portal hypertension (INCPH) has been reported increasingly in patients with HIV infection. To evaluate the number of nationwide diagnosed HIV-associated INCPH cases and to assess its clinical features, risk factors and outcome. All HIV centres in the Netherlands
Elizabeth Ojewole et al.
Planta medica, 78(4), 354-361 (2011-12-14)
The buccal mucosal route offers several advantages but the delivery of certain drugs can be limited by low membrane permeability. This study investigated the buccal permeability properties of didanosine (ddI) and assessed the potential of Aloe vera gel (AVgel) as
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