B9686
Monoclonal Anti-Brain-derived Neurotrophic Factor antibody produced in mouse
clone 37129, purified immunoglobulin, lyophilized powder
Synonym(s):
Anti-BDNF
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About This Item
MDL number:
UNSPSC Code:
51111800
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
37129, monoclonal
form
lyophilized powder
species reactivity
human
technique(s)
capture ELISA: 2 μg/mL
isotype
IgG2a
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... BDNF(627)
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General description
Brain derived neurotrophic factor (BDNF) belongs to a family of secreted proteins called neurotrophins that includes, nerve growth factor (NGF), neurotrophin-3 (NT3) and NT4/5. BDNF is expressed in the developing and the mature brain. The influence of BDNF is mediated by its binding to TrkB receptor and sometimes the receptor p75NTR. The downstream pathways promoted by BDNF include PI3K, MAPK and JAK/STAT. The most important role of BDNF is the regulation of synaptic transmission and plasticity, protein synthesis and phosphorylation of local proteins. The secretion of BDNF is highly regulated at both transcriptional and translational levels since it is involved in the proper function of neuronal circuit and development of cognitive functions. The deficits in BDNF functions are implicated in a number of neurodegenerative disorders such as Huntington′s disease, schizophrenia and dementia
Monoclonal Anti-Brain-derived Neurotrophic Factor detects human BDNF.
Monoclonal Anti-Brain-derived Neurotrophic Factor detects human BDNF.
Immunogen
purified, Sf21-derived recombinant human brain-derived neurotrophic factor.
Application
Monoclonal Anti-Brain-derived Neurotrophic Factor may be used to detect human BDNF by ELISA using a working antibody concentration of 2 μg/ml.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Brain-derived neurotrophic factor and the development of structural neuronal connectivity
Cohen-Cory S et al
Developmental neurobiology, 70, 271-278 (2012)
Jordi Alberch et al.
Progress in brain research, 146, 195-229 (2004-01-01)
Huntington's disease is a neurodegenerative disorder characterized by the selective loss of striatal neurons and, to a lesser extent, cortical neurons. The neurodegenerative process is caused by the mutation of huntingtin gene. Recent studies have established a link between mutant
Mark P Mattson et al.
Trends in neurosciences, 27(10), 589-594 (2004-09-18)
Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine, 5-HT) are known to regulate synaptic plasticity, neurogenesis and neuronal survival in the adult brain. These two signals co-regulate one another such that 5-HT stimulates the expression of BDNF, and BDNF enhances the
Bai Lu et al.
Novartis Foundation symposium, 289, 119-129 (2008-05-24)
BDNF is a key regulator of synaptic plasticity and hence is thought to be uniquely important for various cognitive functions. While correlations of schizophrenia with polymorphisms in the BDNF gene and changes in BDNF mRNA levels have been reported, specific
Emily G Waterhouse et al.
Molecular and cellular neurosciences, 42(2), 81-89 (2009-07-07)
Substantial evidence indicates that brain-derived neurotrophic factor (BDNF) plays a crucial role in synaptic plasticity. Long-lasting synaptic plasticity is restricted to active synapses and requires new protein synthesis. Recent work has identified local protein synthesis as an important source for
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