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Key Documents

AV44083

Sigma-Aldrich

Anti-SLC5A11 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-KST1, Anti-RKST1, Anti-SGLT6, Anti-SMIT2, Anti-Solute carrier family 5 (sodium/glucose cotransporter), member 11

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

74 kDa

species reactivity

horse, mouse, goat, human, guinea pig, rat, bovine, rabbit, dog

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_443176

UniProt accession no.

Q8WWX8

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SLC5A11(115584)

Immunogen

Synthetic peptide directed towards the middle region of human SLC5A11

Application

Anti-SLC5A11 antibody produced in rabbit is suitable for western blotting at a concentration of 1.0μg/ml.

Biochem/physiol Actions

SLC5A11 is a sodium/glucose cotransporter that uses ion gradients to drive active transport of nutrients, neurotransmitters, osmolytes and ions. It interacts with TNF-α, programmed cell death 1 (PDCD1) and complement component 4 (C4) and may induce apoptosis via the TNF-α - PDCD1 pathway. The gene encoding for this transporter also acts as an autoimmune modifier gene.

Sequence

Synthetic peptide located within the following region: VGGMEGLKEKYFLALASNRSENSSCGLPREDAFHIFRDPLTSDLPWPGVL

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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L-J Tsai et al.
Tissue antigens, 71(2), 114-126 (2007-12-12)
Genetic studies in several human autoimmune diseases suggest that the pericentromeric region of chromosome 16 might harbor an autoimmune modifier gene. We hypothesized that the sodium-dependent glucose cotransporter gene SLC5A11 is such a gene, and so might interact with immune-related

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