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Key Documents

AV03050

Sigma-Aldrich

Anti-CDK8 antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-Cyclin-dependent kinase 8

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About This Item

MDL number:
MFCD02262687
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

53 kDa

species reactivity

rabbit, bovine, dog, human, mouse, pig, horse

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_001251

UniProt accession no.

P49336

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... CDK8(1024)

Immunogen

Synthetic peptide directed towards the C terminal region of human CDK8

Application

Anti-CDK8 antibody produced in rabbit is suitable for western blotting at a concentration of 1.25 μg/ml.

Biochem/physiol Actions

CDK8 is a regulator of transcription in a multisubunit complex with TFIIH and TEF-β. It exerts positive and negative effects on transcription and is involved signaling that controls nutrient sensing and cell differentiation. CDK8 phosphorylates the regulatory serine residue of STAT1 and mediates JAK-STAT1 signaling.

Sequence

Synthetic peptide located within the following region: GLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Julia Staab et al.
JAK-STAT, 2(3), e24275-e24275 (2013-09-27)
Whereas cytokine-induced tyrosine phosphorylation of STAT (signal transducer and activator of transcription) proteins by JAK kinases has been well studied, much less is known about STAT-specific serine kinases and their signal-dependent regulation. The paper by Joanna Bancerek and colleagues published
Josipa Nemet et al.
Biochimie, 97, 22-27 (2013-10-22)
Three cyclin dependent kinases, Cdk7, Cdk8 and Cdk9 are intimately connected with the processes of RNA polymerase II dependent transcription initiation and elongation in eukaryotic cells. Each of these kinases is part of a larger multisubunit complex, TFIIH, Mediator and

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