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A0476

Sigma-Aldrich

Activin Receptor-Like Kinase 1/Fc Chimera human

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

Synonym(s):

ALK-1

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About This Item

MDL number:
MFCD03702792
UNSPSC Code:
51111800
NACRES:
NA.32

biological source

human

Quality Level

100

recombinant

expressed in NSO cells

assay

>90% (SDS-PAGE)

form

lyophilized powder

mol wt

50-55 kDa by SDS-PAGE (reducing)
calculated mol wt ~37.3 kDa

packaging

pkg of 100 μg

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P37023

storage temp.

−20°C

Gene Information

human ... ACVRL1(94)

Biochem/physiol Actions

ALK-1 is a type I complex of the serine/threonine kinases. Type I and II receptors bind ligands in the TGF-β superfamily. Human and mouse ALK-1 share approximately 71% amino acid sequence identity in their extracellular domains.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Analysis Note

Can be used as a calibrator for ALK-1 antibodies.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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A Lux et al.
The Journal of biological chemistry, 274(15), 9984-9992 (1999-04-03)
Germ line mutations in one of two distinct genes, endoglin or ALK-1, cause hereditary hemorrhagic telangiectasia (HHT), an autosomal dominant disorder of localized angiodysplasia. Both genes encode endothelial cell receptors for the transforming growth factor beta (TGF-beta) ligand superfamily. Endoglin
P ten Dijke et al.
Oncogene, 8(10), 2879-2887 (1993-10-01)
Human cDNA clones encoding four novel putative transmembrane protein serine/threonine kinases, denoted activin receptor-like kinase (ALK) -1, -2, -3 and -4, were obtained using a polymerase chain reaction (PCR)-based strategy. The PCR primers were designed based upon the sequence similarity

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