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62962

Sigma-Aldrich

L-α-Lysophosphatidylcholine

egg yolk, ≥99.0% (TLC)

Synonym(s):

3-sn-Lysophosphatidylcholine, L-α-Lysolecithin

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About This Item

MDL number:
MFCD00131444
UNSPSC Code:
51321705
NACRES:
NA.25

biological source

egg yolk

description

zwitterionic

assay

≥99.0% (TLC)

form

powder or solid

composition

16:0, ~69% (fatty acid)
18:0, ~27% (fatty acid)
18:1, ~3% (fatty acid)

solubility

chloroform/methanol: 50 mg/mL, clear, colorless to very faintly yellow

functional group

phospholipid

lipid type

phosphoglycerides

shipped in

wet ice

storage temp.

−20°C

Application


  • The activation mode of the mechanosensitive ion channel, MscL, by lysophosphatidylcholine differs from tension-induced gating: L-α-LPC is explored for its unique interaction with ion channels, suggesting its potential as a tool for studying channel mechanics and developing new therapeutic strategies for diseases linked to cellular mechanics (Mukherjee et al., 2014).

  • Aerosol delivery of an enhanced helper-dependent adenovirus formulation to rabbit lung using an intratracheal catheter: The use of L-α-LPC in enhancing the delivery of gene therapy vectors via aerosol demonstrates its utility in improving the efficiency of gene therapies, particularly for respiratory diseases (Koehler et al., 2005).

Biochem/physiol Actions

3-sn-Lysophosphatidylcholine, besides contributing to the positive curvature of membranes , inhibits SNARE complex disassembly in vitro and in rat nerve terminals and exocrine pancrease .

Other Notes

Preparation of demembranated frog sperm chromatin

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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Priscila M Hiraiwa et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 93(7), 727-736 (2018-08-18)
Trypanosomatid parasites are causative agents of neglected human diseases. Their lineage diverged early from the common eukaryotic ancestor, and they evolved singular mechanisms of gene expression that are crucial for their survival. Studies on unusual and essential molecular pathways lead
Harvey T McMahon et al.
Nature, 438(7068), 590-596 (2005-12-02)
Membrane curvature is no longer seen as a passive consequence of cellular activity but an active means to create membrane domains and to organize centres for membrane trafficking. Curvature can be dynamically modulated by changes in lipid composition, the oligomerization
Fengfeng Lu et al.
Neuroscience bulletin, 35(3), 434-446 (2019-01-27)
The obstacle to successful remyelination in demyelinating diseases, such as multiple sclerosis, mainly lies in the inability of oligodendrocyte precursor cells (OPCs) to differentiate, since OPCs and oligodendrocyte-lineage cells that are unable to fully differentiate are found in the areas
Nuclear envelope assembly following mitosis.
R Pfaller et al.
Methods in enzymology, 219, 60-72 (1992-01-01)
Beibei Duan et al.
Molecules (Basel, Switzerland), 26(6) (2021-04-04)
Fat globule size and phospholipid (PL) content in human milk (HM) were investigated. HM was classified into three groups depending on fat content (A < B < C). PL content (mg/100 g HM) was significantly higher in the C group
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