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283M-1

Sigma-Aldrich

HBME-1 (HBME-1) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

HBME-1, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (283M-14)
vial of 0.5 mL concentrate (283M-15)
bottle of 1.0 mL predilute (283M-17)
vial of 1.0 mL concentrate (283M-16)
bottle of 7.0 mL predilute (283M-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgMκ

control

mesothelioma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, membranous

Related Categories

General description

Hector Battifora mesothelial-1 (HBME-1) is a membrane antigen that exists in the microvilli ofmesothelial cells and other epithelial cells. Anti-HBME-1 labels thyroid papillary carcinomaand follicular carcinoma but not normal thyroid making it a valuable marker for distinguishingthyroid malignancies from benign thyroid lesions. It has also been demonstrated to labelmesothelial cells, both benign and malignant (malignant mesothelioma), and thus can aid inthe identification of mesothelioma.

Quality


IVD
IVD
IVD
RUO

Linkage

HBME-1 Positive Control Slides, Product No. 283S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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J E Barroeta et al.
Endocrine pathology, 17(3), 225-234 (2007-02-20)
Several immunohistochemical markers have been used to aid in the diagnosis of follicular-derived lesions of the thyroid (FDLT). In this study we analyze the diagnostic efficacy of an immunopanel of antibodies to cytokeratin-19 (CK19), galectin-3 (GAL-3), HBME-1, anti-MAP kinase (ERK)
Daniela Cabibi et al.
Thyroid : official journal of the American Thyroid Association, 17(7), 603-607 (2007-08-19)
To verify whether immunohistochemistry might be useful in the distinction between a true laterocervical metastasis of an undetected thyroid carcinoma and a primary tumor outside the gland. Galectin-3, cytokeratin 19, and HBME-1 were assessed in six cases (group A) of
A Coli et al.
Journal of experimental & clinical cancer research : CR, 26(2), 221-227 (2007-08-30)
Ninety-six thyroid lesions were immunohistochemically evaluated for HBME-1 and Galectin-3 expression including nodules with cytological atypia, the latter defined as nuclear features suggestive but not diagnostic of papillary thyroid carcinoma. Thirty nodules with cytological atypia, 49 papillary thyroid carcinomas (PTCs)
Liborio Torregrossa et al.
Human pathology, 38(10), 1482-1488 (2007-06-29)
The histologic diagnosis of the follicular variant of papillary thyroid carcinoma (FVPTC) may be troublesome, especially in its encapsulated form. We evaluated the expression of galectin-3 (gal-3) and Hector Battifora mesothelial cell (HBME-1) in 200 formalin-fixed thyroid tissues with diagnosis

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