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Key Documents

T1600000

α-Tocopherol acetate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

DL-α-Tocopherol acetate, Vitamin E acetate, all-rac-α-Tocopheryl acetate

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About This Item

Empirical Formula (Hill Notation):
C31H52O3
CAS Number:
Molecular Weight:
472.74
Beilstein/REAXYS Number:
97512
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

biological source

synthetic

grade

pharmaceutical primary standard

agency

EP

API family

tocopherol

form

liquid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

density

0.96 g/mL at 20 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1

InChI

1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1

InChI key

ZAKOWWREFLAJOT-CEFNRUSXSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. α-Tocopherol acetate, a supplement of α-tocopherol, is an active form of vitamin E. This lipid-soluble antioxidant is found in whole grains, nuts, and oils. It is known to scavenge reactive oxygen species by interacting with lipids during oxidative stress.

Application

α-Tocopherol acetate may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

No data available

flash_point_c

No data available


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ANTIOXIDANTS-Role of Antioxidant Nutrients in Defense Systems
Encyclopedia of food sciences and nutrition, 282-289 (2003)
RRR-?-Tocopheryl acetate
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 3804-3805 (2013)
Determination of eight water-and fat-soluble vitamins in multi-vitamin pharmaceutical formulations by high-performance liquid chromatography
Moreno P and Salvado V
Journal of Chromatography A, 870(1-2), 207-215 (2000)
Flow injection spectrophotometric determination of vitamin E in pharmaceuticals, milk powder and blood serum using potassium ferricyanide-Fe (III) detection system
Jadoon S, et al.
Chinese Chemical Letters = Zhongguo Hua Xue Kuai Bao, 21(6), 712-715 (2010)
The role of alpha-tocopherol in plant stress tolerance
Munne-Bosch S
Journal of Plant Physiology, 162(7), 743-748 (2005)

Protocols

Separation of Retinyl acetate, analytical standard; δ-Tocopherol, analytical standard; Ergocalciferol (D2), analytical standard; Cholecalciferol (D3), analytical standard; (±)-α-Tocopherol, analytical standard; Vitamin E acetate, analytical standard; Phylloquinone (K1), analytical standard; Retinol palmitate, analytical standard.

Separation of Retinyl acetate, analytical standard; Vitamin E acetate, analytical standard; Phylloquinone (K1), analytical standard; Ergocalciferol (D2), analytical standard; Cholecalciferol (D3), analytical standard; (±)-α-Tocopherol, analytical standard; δ-Tocopherol, analytical standard; Retinol palmitate, analytical standard

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