SMB00913

BAA485 (12-Ketodeoxycholic acid)

≥95% (HPLC)

• Synonym(s): BAA485 (12-Ketodeoxycholic acid), (3α,5β)-3-Hydroxy-12-oxocholan-24-oic acid, 12-Dehydrodeoxycholic acid, 12-Oxolithocholic acid, 3α-Hydroxy-12-oxo-5β-cholan-24-oic acid, 3α-Hydroxy-12-oxo-5β-cholanic acid
• Empirical Formula (Hill Notation): C₂₄H₃₈O₄
• CAS Number: 5130-29-0
• Molecular Weight: 390.56
• UNSPSC Code: 41141802
• NACRES: NA.25

Properties

• assay: ≥95% (HPLC)
• form: powder
• quality: 100
• composition: (3α,5α)-3-Hydroxy-12-oxocholan-24-oic acid, ≤100%
• packaging: pkg of 25 mg
• color: white to beige
• mp: 165—167 °C
• solubility: methanol: 20 mg/mL
• storage temp.: 2-8°C
• SMILES string: C[C@H](CCC(O)=O)C1CC[C@@]([C@]21C)([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC2=O
• InChI: 1S/C24H38O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-20,25H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,23+,24-/m1/s1
• InChI key: CVNYHSDFZXHMMJ-VPUMZWJWSA-N

Description

General description

BAA485 (12-oxolithocholic acid) is a microbiome-produced derivative of deoxycholic acid and it is a potent activator of the Pyrin inflammasome. BAA485 induces secretion of IL18 in LPS-primed PBMCs.

Bile acids, natural steroid amphipathic compounds formed through cholesterol oxidation in the liver, play a crucial role in regulating lipid metabolism. They facilitate the digestion, absorption, and transport of lipids, lipid-soluble vitamins, and related molecules in the gastrointestinal tract. These bile acids also impact various aspects of cholesterol, glucose, and energy balance.

Application

BAA485 (12-oxolithocholic acid) finds application in metabolomics, biochemical and microbiome research.

Features and Benefits

• Can be used in Metabolomics and Biochemical research
• High-quality compound suitable for multiple research applications

Other Notes

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Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable