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S2190000

Sulpiride

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(±)-Sulpiride, (±)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide, (±)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide

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About This Item

Empirical Formula (Hill Notation):
C15H23N3O4S
CAS Number:
15676-16-1
Molecular Weight:
341.43
MDL number:
MFCD00055061
UNSPSC Code:
41116107
PubChem Substance ID:
329824513
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

sulpiride

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CCN1CCCC1CNC(=O)c2cc(ccc2OC)S(N)(=O)=O

InChI

1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)

InChI key

BGRJTUBHPOOWDU-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Sulpiride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361

pcodes

P280

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Lot/Batch Number

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Sigma-Aldrich

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Sigma-Aldrich

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Sulpiride augmentation for schizophrenia.
Jijun Wang et al.
Schizophrenia bulletin, 36(2), 229-230 (2010-01-12)
Jijun Wang et al.
The Cochrane database of systematic reviews, (1)(1), CD008125-CD008125 (2010-01-22)
Sulpiride may be used in combination with other antipsychotic drugs in the hope of augmenting effectiveness - especially for those whose schizophrenia has proved resistant to treatment. To evaluate the effects of sulpiride augmentation versus monotherapy for people with schizophrenia.
Ichiro M Omori et al.
The Cochrane database of systematic reviews, (2)(2), CD007811-CD007811 (2009-04-17)
Sulpiride is a relatively old antipsychotic drug reputed to have low incidence of adverse effects and an effect on the negative symptoms of schizophrenia. This relatively inexpensive antipsychotic drug has a similar neuropharmacological profile to several novel atypical drugs. To
G Serra et al.
Clinical neuropharmacology, 13 Suppl 1, S76-S83 (1990-01-01)
L-Sulpiride is a dopamine (DA)-receptor blocker that acts as an antidepressant at low doses. We have reviewed evidence suggesting that the antidepressant effect of L-sulpiride may depend on the activation of DA transmission secondary to the blockade of DA autoreceptors.
J H Stubbs et al.
Acta psychiatrica Scandinavica, 102(5), 390-393 (2000-12-01)
Schizophrenic patients who are only partially responsive to clozapine pose a therapeutic challenge. In these circumstances some clinicians would consider adding in a second antipsychotic. We present a case report and review evidence for the efficacy of such augmentation strategies.
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