PHR2077

Risedronate Related Compound C

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): 2-(3-Pyridinyl)ethylidene]bis(phosphonic acid), 2-(Pyridin-3-yl)ethane-1,1-diyl]bis(phosphonic acid)
• Empirical Formula (Hill Notation): C₇H₁₁NO₆P₂
• CAS Number: 75755-10-1
• Molecular Weight: 267.11
• Beilstein/REAXYS Number: 9562253
• MDL number: MFCD26142887
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• agency: traceable to Ph. Eur. Y0001540; traceable to USP 1604643
• API family: risedronate
• CofA: current certificate can be downloaded
• packaging: pkg of 50 mg
• application(s): pharmaceutical
• format: neat
• storage temp.: 2-30°C
• SMILES string: OP(O)(C(CC1=CN=CC=C1)P(O)(O)=O)=O
• InChI: 1S/C7H11NO6P2/c9-15(10,11)7(16(12,13)14)4-6-2-1-3-8-5-6/h1-3,5,7H,4H2,(H2,9,10,11)(H2,12,13,14)
• InChI key: KZMOFWIRXNQJET-UHFFFAOYSA-N

Description

General description

Risedronate Related Compound C is an impurity of risedronate, belonging to the group of pyridinyl bisphosphonates, and is effectively used in the treatment of Paget′s disease of bone. It is also used for the treatment of skeletal disorders since it inhibits osteoclast-mediated bone resorption and modulates bone metabolism.

Application

Risedronate may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase ion-pair high-performance liquid chromatographic method.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB8927 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• pictograms: GHS08
• signalword: Warning
• hcodes: H361
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable