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N0750015

Nifedipine impurity B

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Dimethyl 2,6-dimethyl-4-(2-nitrosophenyl)-3,5-pyridinedicarboxylate

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About This Item

Empirical Formula (Hill Notation):
C17H16N2O5
CAS Number:
50428-14-3
Molecular Weight:
328.32
MDL number:
MFCD22572715
UNSPSC Code:
41116107
PubChem Substance ID:
329818457
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

nifedipine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

O=C(OC)C1=C(C2=C(N=O)C=CC=C2)C(C(OC)=O)=C(C)N=C1C

InChI

1S/C17H16N2O5/c1-9-13(16(20)23-3)15(11-7-5-6-8-12(11)19-22)14(10(2)18-9)17(21)24-4/h5-8H,1-4H3

InChI key

MUZLTKGYFZENFW-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Nifedipine impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Related product

Product No.
Description
Pricing

1463508

Nifedipine, United States Pharmacopeia (USP) Reference Standard

N0750000

Nifedipine, European Pharmacopoeia (EP) Reference Standard

N0750010

Nifedipine impurity A, European Pharmacopoeia (EP) Reference Standard

1463600

Nifedipine Nitrophenylpyridine Analog, United States Pharmacopeia (USP) Reference Standard

1463701

Nifedipine Nitrosophenylpyridine Analog, United States Pharmacopeia (USP) Reference Standard

PHR1290

Nifedipine, Pharmaceutical Secondary Standard; Certified Reference Material

BP462

Nifedipine, British Pharmacopoeia (BP) Reference Standard

BP866

Dimethyl 2,6-dimethyl-4-(2-nitrosophenyl)-3,5-pyridinedicarboxylate, British Pharmacopoeia (BP) Reference Standard

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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V Misík et al.
Molecular pharmacology, 40(3), 435-439 (1991-09-01)
Nifedipine [1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic+ ++ acid dimethyl ester] and nimodipine [1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic+ ++ acid 2-methoxyethyl 1-methylethyl ester], incorporated into diheptanoylphosphatidylcholine liposomes, which were used as a drug carrier system, slightly inhibited lipid peroxidation (induced by tert-butylhydroperoxide and Fe2+) in rat heart homogenate. Illumination
G Carlucci et al.
Farmaco (Societa chimica italiana : 1989), 45(6 Suppl), 751-755 (1990-06-01)
A method for the determination of 2,6-dimethyl-4-(2'-nitrosophenyl)-3,5-pyridinedicarboxylic acid dimethylester in nifedipine (bulk material and pharmaceutical formulations) by second-derivative ultraviolet spectrophotometry is described. The procedure is simple and rapid and gives accurate and precise results.
Jürgen Schoppe et al.
Cell calcium, 33(3), 207-221 (2003-02-26)
Leech P neurons possess caffeine-sensitive ion channels in intracellular Ca(2+) stores and in the plasma membrane. The following results indicate that these channels are also activated by 2,6-dimethyl-4-(2-nitrosophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester (NTP), the photoproduct of the L-type Ca(2+) channel-blocker nifedipine:

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