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D1039990

Diclofenac potassium

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Diclofenac potassium salt, 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid potassium salt

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About This Item

Empirical Formula (Hill Notation):
C14H10Cl2KNO2
CAS Number:
15307-81-0
Molecular Weight:
334.24
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

diclofenac

manufacturer/tradename

EDQM

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

InChI

1S/C14H11Cl2NO2.K/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1

InChI key

KXZOIWWTXOCYKR-UHFFFAOYSA-M

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Diclofenac potassium EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Related product

Product No.
Description
Pricing

PHR1144

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S0765000

Diclofenac sodium, European Pharmacopoeia (EP) Reference Standard

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N-(2,6-Dichlorophenyl)-2-indolinone, analytical standard

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Diclofenac potassium, United States Pharmacopeia (USP) Reference Standard

BP619

Diclofenac sodium, British Pharmacopoeia (BP) Reference Standard

BP828

N-(2,6-Dichlorophenyl)-2-indolinone, British Pharmacopoeia (BP) Reference Standard

BP598

Diclofenac diethylamine, British Pharmacopoeia (BP) Reference Standard

PHR2443

Diclofenac Impurity E, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2446

Diclofenac Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2447

Diclofenac Impurity D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2445

Diclofenac Impurity C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2444

Diclofenac Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2442

Diclofenac Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H411

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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The NSAID diclofenac is a potent inhibitor of prostaglandin synthesis and an established antipyretic and analgesic agent. Diclofenac-potassium was developed as an immediate-release tablet with the aim of providing rapid onset of action after oral administration. This formulation has been
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Diclofenac residues have been found in surface water, and thus could present a potential risk to aquatic species. The aim of this study was to assess the impact of diclofenac on the mortality, growth, and development of fish, as well
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Renal function and disease are commonly evaluated by radionuclide studies. The choice of radiopharmaceutical agent for various studies is crucial for proper interpretation. (99m)Tc-mercaptoacetyltriglycine ((99m)Tc-MAG3) is excreted almost exclusively by the renal tubules, whereas (99m)Tc-diethylenetriamine pentaacetic acid ((99m)Tc-DTPA) is predominantly
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The aim of this work was to synthesize an ester prodrug of diclofenac and β-cyclodextrin suitable for colonic delivery. The synthesis of an ester linkage between diclofenac and β-cyclodextrin was conducted by the nucleophilic substitution of mono-6-tosyl-β-cyclodextrin under microwaves irradiation.
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