938963

Potassium tert-butoxide ChemBeads

• Synonym(s): Potassium tert-butylate, Potassium t-butoxide
• Empirical Formula (Hill Notation): KOC₄H₉
• CAS Number: 865-47-4
• Molecular Weight: 112.21
• MDL number: MFCD00012162
• UNSPSC Code: 12352100

Properties

• description: Reagent Type-Organic Salt
• Quality Level: 100
• form: solid
• composition: wt% loading of base, 14-16 wt. %
• reaction suitability: core: potassium
• SMILES string: [K+].CC(C)(C)[O-]
• InChI: 1S/C4H9O.K/c1-4(2,3)5;/h1-3H3;/q-1;+1
• InChI key: LPNYRYFBWFDTMA-UHFFFAOYSA-N

Description

General description

Potassium tert-butoxide is a strong alkoxide base, it can deprotonate carbon and other Brφnsted acids. It is a relatively poor nucleophile.

Application

Potassium tert-butoxide has been used as a strong base in the enantioselective synthesis of amines by transfer hydrogenation of N-(tertbutylsulfinyl)imines. It can also be used: To synthesize aliphatic and aromatic amides from corresponding esters and amines. As a base in the intramolecular cyclization of aryl ethers, amines, and amides. As a catalyst to prepare styrene derivatives from aryl halides and alkenes by Mizoroki-Heck reaction.
For general uses, product is also available in powdered form (156671)

Features and Benefits

ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.

Other Notes

High-Throughput Reaction Screening with Nanomoles of Solid Reagents Coated on Glass Beads

Versatile Methods to Dispense Sub-Milligram Quantities of Solids using Chemical Coated Beads for High-Throughput Experimentation

ChemBead Enabled High-Throughput Cross-Electrophile Coupling Reveals a New Complementary Ligand

Safety Information

• pictograms: GHS02,GHS05
• signalword: Danger
• hcodes: H228,H252,H314
• pcodes: P210 - P235 - P260 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Flam. Sol. 1 - Self-heat. 2 - Skin Corr. 1A
• supp_hazards: EUH014
• Storage Class: 4.2 - Pyrophoric and self-heating hazardous materials
• wgk_germany: WGK 3