90240

Glyceryl triacetate

≥99.0% (GC)

• Synonym(s): 1,2,3-Triacetoxypropane, 1,2,3-Triacetylglycerol, Glycerol triacetate, Triacetin
• Linear Formula: (CH₃COOCH₂)₂CHOCOCH₃
• CAS Number: 102-76-1
• Molecular Weight: 218.20
• Beilstein/REAXYS Number: 1792353
• EC Number: 203-051-9
• MDL number: MFCD00008716
• UNSPSC Code: 12352211
• PubChem Substance ID: 329769862
• NACRES: NA.25

Properties

• Quality Level: 200
• assay: ≥99.0% (GC)
• form: liquid
• refractive index: n20/D 1.431
• bp: 258-260 °C (lit.)
• density: 1.158 g/mL at 20 °C
• lipid type: saturated FAs
• SMILES string: CC(=O)OCC(COC(C)=O)OC(C)=O
• InChI: 1S/C9H14O6/c1-6(10)13-4-9(15-8(3)12)5-14-7(2)11/h9H,4-5H2,1-3H3
• InChI key: URAYPUMNDPQOKB-UHFFFAOYSA-N

Description

Application

• Epigenetic priming targets tumor heterogeneity to shift transcriptomic phenotype of pancreatic ductal adenocarcinoma towards a Vitamin D susceptible state.: This groundbreaking study utilizes glyceryl triacetate as part of an epigenetic priming strategy to sensitize pancreatic ductal adenocarcinoma to Vitamin D, marking a significant advancement in cancer treatment modalities (He et al., 2024).


• Glyceryl triacetate promotes blood-brain barrier recovery after ischemic stroke through lipogenesis-mediated IL-33 in mice.: Research demonstrates glyceryl triacetate′s effectiveness in enhancing blood-brain barrier repair post-ischemic stroke via lipogenesis pathways, offering insights into novel stroke recovery treatments (Wei et al., 2023).


• Development of A Nanostructured Lipid Carrier-Based Drug Delivery Strategy for Apigenin: Experimental Design Based on CCD-RSM and Evaluation against NSCLC In Vitro.: This study details the formulation of a nanostructured lipid carrier incorporating glyceryl triacetate, optimized for delivering apigenin to combat non-small cell lung cancer, emphasizing the potential of glyceryl triacetate in targeted therapy applications (Wang et al., 2023).


• Are New Phthalate Ester Substitutes Safer than Traditional DBP and DiBP Comparative Endocrine-Disrupting Analyses on Zebrafish Using In Vivo, Transcriptome, and In Silico Approaches.: Investigating glyceryl triacetate as a safer alternative to traditional phthalate esters, this study explores its lower endocrine-disrupting effects, contributing to safer industrial and pharmaceutical applications (Tan et al., 2023).


• Glyceryl triacetate feeding in mice increases plasma acetate levels but has no anticonvulsant effects in acute electrical seizure models.: This research evaluates the biochemical impact of glyceryl triacetate on plasma acetate levels, providing valuable data on its metabolic effects despite a lack of anticonvulsant properties in specific seizure models (Xu et al., 2022).

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: 298.4 °F - closed cup
• flash_point_c: 148 °C - closed cup
• ppe: Eyeshields, Gloves