46656

Prednisolone

VETRANAL^®, analytical standard

• Synonym(s): 1,4-Pregnadiene-11β,17α,21-triol-3,20-dione, 1-Dehydrocortisol, 1-Dehydrohydrocortisone, 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione
• Empirical Formula (Hill Notation): C₂₁H₂₈O₅
• CAS Number: 50-24-8
• Molecular Weight: 360.44
• Beilstein/REAXYS Number: 1354103
• EC Number: 200-021-7
• MDL number: MFCD00003649
• UNSPSC Code: 41116107
• PubChem Substance ID: 329756614
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 100
• product line: VETRANAL^®
• shelf life: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 240 °C (dec.) (lit.)
• application(s): forensics and toxicology; pharmaceutical (small molecule)
• format: neat
• SMILES string: O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1
• InChI: 1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• InChI key: OIGNJSKKLXVSLS-VWUMJDOOSA-N
• Gene Information: human ... NR3C1(2908)

Description

General description

Prednisolone is classified under the corticosteroids class of compounds.

Application

Prednisolone may be used as an analytical standard for the determination of prednisolone in:

• Human plasma by multivariate curve resolution-alternating least squares (MCR-ALS) technique combined with high performance liquid chromatography-diode array detection (HPLC-DAD).
• Urine, blood and food matrices by solid-phase extraction (SPE) and LC coupled to tandem mass spectrometry (LC-MS/MS).
• Surface water samples by SPE and ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOF) with electrospray ionization (ESI).
• Bovine muscle samples by ESI-LC-MS/MS equipped with multiple reaction monitoring (MRM) detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H360FD
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 2
• ppe: dust mask type N95 (US), Eyeshields, Gloves