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Supelco

Rafoxanide

PESTANAL®, analytical standard

Synonym(s):

3′-Chloro-4′-(4-chlorophenoxy)-3,5-diiodosalicylanilide

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About This Item

Empirical Formula (Hill Notation):
C19H11Cl2I2NO3
CAS Number:
22662-39-1
Molecular Weight:
626.01
EC Number:
245-148-9
MDL number:
MFCD00682899
UNSPSC Code:
41116107
PubChem Substance ID:
329754777
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

PESTANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

agriculture
environmental

format

neat

SMILES string

Oc1c(I)cc(I)cc1C(=O)Nc2ccc(Oc3ccc(Cl)cc3)c(Cl)c2

InChI

1S/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9,25H,(H,24,26)

InChI key

NEMNPWINWMHUMR-UHFFFAOYSA-N

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General description

Rafoxanide is a halogenated salicylanilide and an anthelmintic agent. It is widely used against fasciolosis and haemonchosis in sheep and cattle. It also finds applications as an adulticide for Fasciola hepatica and Fasciola gigantica.

Application

Rafoxanide may be used as a reference standard in the determination of rafoxanide in plasma and tissue samples using high-performance liquid chromatography (HPLC) coupled with an ultraviolet detector and thermospray − mass spectrometry.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

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Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCBZ3293
SZBD304XV
SZBA292XV
SEZ91
SZE9140X

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R M Waruiru et al.
Veterinary parasitology, 75(2-3), 191-197 (1998-06-24)
The anthelmintic efficacy of benzimidazoles, levamisole, rafoxanide and ivermectin was evaluated on an institutional farm in Kenya using faecal egg count reduction test, larval cultures and a controlled slaughter trial. The results of this study indicated simultaneous resistance of Haemonchus
Veterinary Pharmacology and Therapeutics (2017)
J A Van Wyk et al.
The Onderstepoort journal of veterinary research, 66(4), 273-284 (2000-02-26)
Surveys to determine the prevalence and degree of resistance of Haemonchus spp. of sheep and goats to the available anthelmintics in South Africa indicate that small ruminant production is entering a crisis situation. Three surveys employing the faecal egg count
J A van Wyk et al.
Veterinary parasitology, 72(2), 157-165 (1997-12-24)
We became increasingly concerned about indications of possible substandard efficacy of some generic anthelmintics, particularly after P.C. van Schalkwyk (personal communication, 1990) had found some batches of imported generic products obtained from international brokers to be poorly active, despite apparently
J H Gill et al.
International journal for parasitology, 25(4), 463-470 (1995-04-01)
Avermectin (AVM) inhibition of the development of the free-living stages of Haemonchus contortus has been quantified in an assay in which nematode eggs are placed on an agar matrix containing serial dilutions of a drug in the wells of a
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