282820

Protoporphyrin IX zinc(II)

guanylate cyclase inhibitor

• Synonym(s): 3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionic acid, 8,13-Divinyl-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid zinc derivative, Protoporphyrin IX zinc(II) complex
• Empirical Formula (Hill Notation): C₃₄H₃₂N₄O₄Zn
• CAS Number: 15442-64-5
• Molecular Weight: 626.03
• EC Number: 239-455-7
• MDL number: MFCD00011612
• UNSPSC Code: 12171500
• PubChem Substance ID: 24857074
• NACRES: NA.47

Properties

• Quality Level: 100
• assay: ≥92% (HPLC)
• form: powder
• color: red to very dark red
• λmax: 426 nm
• ε (extinction coefficient): ≥10000 at 585-591 nm in pyridine; ≥12000 at 548-554 nm in pyridine; ≥135000 at 423-429 nm in pyridine
• application(s): diagnostic assay manufacturing; hematology; histology
• storage temp.: room temp
• SMILES string: Cc1c(CCC(O)=O)c2cc3c(CCC(O)=O)c(C)c4cc5nc(cc6c(C)c(C=C)c(cc1n2)n6[Zn]n34)c(C=C)c5C
• InChI: 1S/C34H34N4O4.Zn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;
• InChI key: FUTVBRXUIKZACV-RGGAHWMASA-L

Description

General description

Protoporphyrin IX zinc(II) (ZnPP) is an anti-oxidant enzyme heme oxygenase-1.

Application

Cellular melanin content in normal human melanocytes treated with ZnPP has been studied. 1 It was used as a standard in a study where the excess formation of ZnPP in iron deficient erythropoiesis was determined by haematofluorometer.

Inhibits soluble guanylate cyclase.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)